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Got It, Hide thisLivingston G, Kelly L, Lewis-Holmes E, et al. Non-pharmacological interventions for agitation in dementia: systematic review of randomised controlled trials. Br J Psychiatry. 2014;205:436-42.
In people with dementia, do interventions other than drugs reduce agitation?
Many people with dementia become agitated at times (e.g., pace, wander, become restless or aggressive, or have physical or verbal outbursts). Agitation can be distressing for people with dementia and their caregivers.
Interventions that prevent or decrease agitation in people with dementia may reduce distress.
The researchers did a systematic review, searching for studies that were published up to June 2012.
They found 33 randomized controlled trials, each with between 47 and 306 people.
The key features of the randomized controlled trials were:
8 studies across multiple interventions were of high quality. Findings from the randomized controlled trials are reported in the Table.
Training paid caregivers in person-centred care or communication skills and supervising them during training reduces agitation in people with dementia who live in care homes. Working with people with dementia on specific activities also reduces agitation.
Interventions | Number of trials and people | Effects on agitation during intervention | Effects on agitation after intervention |
Training with supervision for paid caregivers in person-centered care or communication skills | 6 trials ( 921 people with no, some, or severe agitation) | Reduced some measures in 6 trials | Reduced some measures at 8 weeks to 6 months in 5 trials |
Training without supervision for paid caregivers in person-centered care or communication skills | 2 trials (237 people with no agitation) | No effect in 2 trials | No effect at 15 weeks in 1 trial |
Training family caregivers in cognitive-behavioural or behavioural management therapy | 4 trials (294 people with some or severe agitation) | No effect in 2 trials Effect unclear in 1 trial | No effect in 3 trials Effect unclear in 1 trial |
Activity-based interventions | 5 trials (510 people with no or some agitation) | Reduced in 4 trials No effect in 1 trial | No effect at 1 week in 1 trial |
Sensory interventions | 6 trials (501 people with no or some agitation) | Reduced in 1 trial using acupressure, 1 trial using hand massage with or without calm music, and 1 trial of Snoezelen therapy (some measures) No effect in 3 trials using therapeutic touch therapy | No effect in 2 trials using therapeutic touch therapy |
Light therapy | 3 trials (210 people with some or severe agitation) | Increased in 2 trials No effect in 1 trial | No effect at 4 weeks in 1 trial |
Music therapy | 3 trials (206 people with no or some agitation) | Reduced in 2 trials No effect in 1 trial | Reduced at 1 month in 1 trial |
Aromatherapy | 2 trials (166 people with severe agitation) | Reduced in 1 trial No effect in 1 trial | — |
Exercise | 1 trial (112 people with no agitation) | No effect | No effect at 7 weeks |
Simulated presence with recordings of relatives | 1 trial (54 people) | No effect | — |
Combinations of interventions | 2 trials (151 people with no or some agitation) | No effect in 2 trials | No effect at 2 months in 1 trial |