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Clinician Article

Statins for the primary prevention of cardiovascular disease.



  • Taylor F
  • Huffman MD
  • Macedo AF
  • Moore TH
  • Burke M
  • Davey Smith G, et al.
Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD004816. doi: 10.1002/14651858.CD004816.pub5. (Review)
PMID: 23440795
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Disciplines
  • Public Health
    Relevance - 7/7
    Newsworthiness - 6/7
  • Internal Medicine
    Relevance - 7/7
    Newsworthiness - 5/7
  • Family Medicine (FM)/General Practice (GP)
    Relevance - 6/7
    Newsworthiness - 5/7
  • General Internal Medicine-Primary Care(US)
    Relevance - 6/7
    Newsworthiness - 5/7
  • Cardiology
    Relevance - 5/7
    Newsworthiness - 4/7

Abstract

BACKGROUND: Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD) events in people with and without a past history of CVD is an important goal of pharmacotherapy. Statins are the first-choice agents. Previous reviews of the effects of statins have highlighted their benefits in people with CVD. The case for primary prevention was uncertain when the last version of this review was published (2011) and in light of new data an update of this review is required.

OBJECTIVES: To assess the effects, both harms and benefits, of statins in people with no history of CVD.

SEARCH METHODS: To avoid duplication of effort, we checked reference lists of previous systematic reviews. The searches conducted in 2007 were updated in January 2012. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2022, Issue 4), MEDLINE OVID (1950 to December Week 4 2011) and EMBASE OVID (1980 to 2012 Week 1).There were no language restrictions.

SELECTION CRITERIA: We included randomised controlled trials of statins versus placebo or usual care control with minimum treatment duration of one year and follow-up of six months, in adults with no restrictions on total, low density lipoprotein (LDL) or high density lipoprotein (HDL) cholesterol levels, and where 10% or less had a history of CVD.

DATA COLLECTION AND ANALYSIS: Two review authors independently selected studies for inclusion and extracted data. Outcomes included all-cause mortality, fatal and non-fatal CHD, CVD and stroke events, combined endpoints (fatal and non-fatal CHD, CVD and stroke events), revascularisation, change in total and LDL cholesterol concentrations, adverse events, quality of life and costs. Odds ratios (OR) and risk ratios (RR) were calculated for dichotomous data, and for continuous data, pooled mean differences (MD) (with 95% confidence intervals (CI)) were calculated. We contacted trial authors to obtain missing data.

MAIN RESULTS: The latest search found four new trials and updated follow-up data on three trials included in the original review. Eighteen randomised control trials (19 trial arms; 56,934 participants) were included. Fourteen trials recruited patients with specific conditions (raised lipids, diabetes, hypertension, microalbuminuria). All-cause mortality was reduced by statins (OR 0.86, 95% CI 0.79 to 0.94); as was combined fatal and non-fatal CVD RR 0.75 (95% CI 0.70 to 0.81), combined fatal and non-fatal CHD events RR 0.73 (95% CI 0.67 to 0.80) and combined fatal and non-fatal stroke (RR 0.78, 95% CI 0.68 to 0.89). Reduction of revascularisation rates (RR 0.62, 95% CI 0.54 to 0.72) was also seen. Total cholesterol and LDL cholesterol were reduced in all trials but there was evidence of heterogeneity of effects. There was no evidence of any serious harm caused by statin prescription. Evidence available to date showed that primary prevention with statins is likely to be cost-effective and may improve patient quality of life. Recent findings from the Cholesterol Treatment Trialists study using individual patient data meta-analysis indicate that these benefits are similar in people at lower (< 1% per year) risk of a major cardiovascular event.

AUTHORS' CONCLUSIONS: Reductions in all-cause mortality, major vascular events and revascularisations were found with no excess of adverse events among people without evidence of CVD treated with statins.


Clinical Comments

Family Medicine (FM)/General Practice (GP)

This supports the UK's guidance from NICE to treat at or above a 10-year estimated risk of 20%. The surrogate marker of changes in blood lipid levels are far less important than the impact on all-cause mortality. Indeed, the paucity of evidence for other modulators of lipid levels (e.g., some non-statin drugs and diet) affecting overall outcomes implies they might be irrelevant.

Family Medicine (FM)/General Practice (GP)

Statins are a truly remarkable group of drugs that help our patients live longer and live better.

General Internal Medicine-Primary Care(US)

Note that while the meta-analysis did show an apparent all-cause mortality benefit, the number needed to treat over 5 years was high (96).

General Internal Medicine-Primary Care(US)

This confirms a gradually evolving story suggesting we lower our threshold for statin use in middle-age and beyond.

General Internal Medicine-Primary Care(US)

Definitely strengthens the case for broader use of statins in primary care.

General Internal Medicine-Primary Care(US)

This meta-analysis does an excellent job describing the small but real benefits of taking statins for patients without cardiovascular disease. I was particularly impressed with the reduction in overall mortality, a measure that is difficult to manipulate.

Internal Medicine

More evidence in favor of statin use for the primary prevention of cardiovascular diseases.

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